5/7/2023 0 Comments Udig fossils![]() The guides are very helpful and will provide tools if you do not choose to bring your own. I found 75+ complete to near complete trilobites in a 5 hour period. This time I found even more fossils than the last (in 2000), including a completely intact 2-inch Elraithia, and numerous complete baby Asaphiscus. One online reviewer said, "I just got back from my second trip to U-dig fossil quarry. The nearest food and gas is in Delta, fifty two miles away. Pick a spot below or above the U-DIG Quarry. You can camp anywhere you want on BLM land. There is no organized camping however much of the land around the U-DIG Quarry is BLM or public land. There is plenty of room for RV's at the site. Leashed dogs are allowed at the quarry, be sure to bring extra water. The quarry accepts cash, checks, and all major credit cards. A discount of 20% is available for Utah residents who can show a driver's license. There is also a discount for Boy Scout groups and local school groups. Group discounts are available for ten or more. Length of stay charges are broken into two, four and eight hour time periods. There is no charge for children under six if accompanied by a paying adult. Age groups are from 7 to 16, and 17 and older. Pricing for the quarry is based on age and length of stay. Inexpensive safety glasses are available at most hardware stores. Splitting rock can create shards of stone, which could injure your eyes if not protected. The quarry is not allowed to provide eye protection due to health concerns. It is also important to bring safety glasses. Depending on the time of your visit, you might want to bring beverages and a light lunch. Wear sturdy shoes to protect your feet from dust and sharp rock and bring a light jacket in case the weather changes. Tips for visiting the quarry - bring a pair of gloves to protect your hands. Any type of vehicle can travel this gravel road. Then travel twenty miles down a well-maintained gravel road to reach the quarry. There is a U-DIG Fossils sign at this intersection. At the Long Ridge Reservoir sign between mile markers 56-57, turn right. ![]() ![]() Once in Delta, travel thirty two miles west on Highway 6 / 50. It is approximately ninety miles from Provo to Delta and approximately one hundred and thirty miles from Salt Lake City to Delta. The quarry is located approximately fifty two miles west of Delta, Utah. Do not attempt to enter the quarry when it is closed. Please arrive at the quarry before 4pm, as it closes early if no one is present by then. It is open on some holidays during the season. Business hours are Monday through Saturday from 9am to 6pm.The quarry is closed on Sundays. The U-DIG Fossils quarry opens for the season in the middle of March. There are toilet facilities at the quarry. They will provide digging instructions and assistance with finding and identifying fossils. The quarry can provide hammers to split the shale, buckets to hold your collection and to transport fossils to your vehicle in the parking area. Fresh rock is exposed with an excavator on a regular basis. These men will you how to split the rock to find trilobites, and can help identify what you find. The U-Dig staff will roam the quarry area and are happy to show you how to find the richest veins of fossil-bearing rock. Most visitors to the park find ten to twenty trilobites in a four-hour period. The fossils range in length from an eighth of an inch, to two inches. Other fossils, including brachiopods, sponges, worm tracks, and phyllocarids, can be uncovered, but they are harder to come by. Alokistocare harrisi, Bolasidella housensis, and Olenoides nevadensis are some of the rarer species that have been found. The most common trilobite species found at the Quarry are: Asaphiscus wheeleri, Elrathia kingi, or Peronopsis interstricta. They are one of the most popular fossils with collectors because there are so many varieties and they are often preserved in excellent condition. These hard-shelled prehistoric critters roamed the sea floor and coral reefs in search of food. U-Dig regularly extracts fresh chunks of fossil-bearing rock with heavy equipment.Ī form of invertebrate marine life, trilobites lived more than 500 million years ago. If you want to dig deeper and remove fresh rock for yourself, larger tools are available. Bring your own hammer, or U-Dig Fossils can provide one. The fossils are found in limestone shale rocks that split easily into flat sheets, revealing the trilobite fossils. Containing one of the world's richest deposits of trilobites, at this site you can dig and find your own fossils. U-Dig Fossils is a private, family run quarry west of Delta, Utah.
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5/7/2023 0 Comments Freeciv net![]() With freeciv-serverArchitecture: amd64Version: 2.6.2-1 package. Or you can use following command also: sudo apt-get purge -auto-remove freeciv-serverArchitecture: amd64Version: 2.6.2-1Ībove command will remove all the configuration files and data associated Topic contains game id, which I can later use to track down. Freeciv-web is an Open Source strategy game which can be played online against other players. This will remove freeciv-serverArchitecture: amd64Version: 2.6.2-1 and all its dependent packages which is no longerĬompletely removing freeciv-serverArchitecture: amd64Version: 2.6.2-1 with all configuration files:įollowing command should be used with care as it deletes all theĬonfiguration files and data: sudo apt-get purge freeciv-serverArchitecture: amd64Version: 2.6.2-1 In the metaservers they show up as Host. ![]() ![]() To remove the freeciv-serverArchitecture: amd64Version: 2.6.2-1 following command is used: sudo apt-get remove freeciv-serverArchitecture: amd64Version: 2.6.2-1įollowing command is used to remove the freeciv-serverArchitecture: amd64Version: 2.6.2-1 package along with itsĭependencies: sudo apt-get remove -auto-remove freeciv-serverArchitecture: amd64Version: 2.6.2-1 For uninstalling this package you can easily use the apt command and remove the package from Linux Operating System. Now we will see the commands for uninstalling the freeciv-serverArchitecture: amd64Version: 2.6.2-1 from Ubuntu 20.04 LTS. How to uninstall/remove freeciv-serverArchitecture: amd64Version: 2.6.2-1 from Ubuntu 20.04 LTS? After completion of the installation you can use the package on your system. If you are not already logged in as su, installer will ask you the root password. It was hosted by Google and SourceForge before moving to Github. Sudo apt-get install freeciv-serverArchitecture: amd64Version: 2.6.2-1Ībove command will confirm before installing the package on your Ubuntu 20.04 LTS Operating System. To compile Freeciv yourself, download the source code: freeciv-3.0.2.tar.xz Mirror 1 () Mirror 2 () freeciv-3.0.2. The freeciv-forever project also known as was the predecessor of Freeciv-web. Use dpkg -contents (= dpkg-deb -contents) to list archive files freeciv-serverArchitecture: amd64Version: 2.6.2-1:Īfter system update use the following command to install freeciv-serverArchitecture: amd64Version: 2.6.2-1: [1mdpkg-query:[0m package 'freeciv-server' is not installed If freeciv-serverArchitecture: amd64Version: 2.6.2-1 is not installed on your compter then the command 'dpkg -L freeciv-serverArchitecture: amd64Version: 2.6.2-1' will give followin dpkg -L freeciv-server This will update the list of newest versions of packages and its dependencies on your system.Īfter downloading the latest package list with the help of above you can run the installation process. Above command will download the package lists for Ubuntu 20.04 LTS on your system. ![]() The Binding of Isaac note More specifically,both Rebirth and its expansion Afterbirth. ![]()
5/6/2023 0 Comments Radium 223 treatment3- 6 However, the majority of the patients eventually develop castration-resistant prostate cancer (CRPC). Docetaxel and drugs interfering with androgen signaling by directly binding to androgen receptor (AR) or inhibiting CYP17A involved in androgen synthesis have increased survival in combination with ADT. 2 Androgen-deprivation therapy (ADT) is the cornerstone for the treatment of metastatic prostate cancer due to the high dependence of prostate cancer cells on androgen signaling. Bone and lymph node metastasis are typical in prostate cancer, but occasionally also visceral or other metastases may be present. 1 The 5-year survival rate for local or regional prostate cancer is over 90%, but metastatic disease remains incurable. Prostate cancer is the second most commonly diagnosed cancer in men and sixth leading cause of cancer-related death among men globally, but even more common cause of cancer-related mortality in Western countries. Our results support using radium-223 for mCRPC patients with symptomatic bone metastases even in the era of new-generation androgen receptor-targeted agents. The efficacy of radium-223 in mCRPC as estimated using OS was comparable to earlier randomized trial in this retrospective real-world study. Pain relief, ALP normalization, lower baseline PSA, and PSA decrease during radium-223 treatment were prognostic for better survival. Radium-223 was well tolerated in routine clinical practice, and most patients achieved pain relief. Only 12.5% of the patients had grade III–IV adverse events, most commonly anemia, neutropenia, leucopenia, and thrombocytopenia. Pain relief indicated better OS ( p = 0.002). Most patients (57%) experienced pain relief. High prostate-specific antigen (PSA) level (≥100 μg/L) before radium-223 treatment was associated with poor OS compared to low PSA level (<20 μg/L) ( p = 0.0001). Alkaline phosphatase (ALP) values within the normal range before and during the radium-223 treatment or the reduction of elevated ALP to normal range during treatment were associated with better OS when compared to elevated ALP values before and during treatment ( p < 0.0001). The median overall survival (OS) was 13.8 months (range 0.5–57 months), and the median real-world progression-free survival (rwPFS) was 4.9 months (range 0.5–29.8 months). We identified 160 patients who had received radium-223 in Finland in 2014–2019. We report results of a retrospective multicenter study including all patients with metastatic CRPC treated with radium-223 in all five university hospitals in Finland since the introduction of the treatment. However, real-world data are also needed with wider inclusion criteria. Results of a previously reported phase III randomized trial showed survival benefit for radium-223 compared to best supportive care in castration-resistant prostate cancer (CRPC) with bone metastases. Radium-233 dichloride is an alpha emitter that specifically targets bone metastases in prostate cancer. 5/6/2023 0 Comments Paranoid android![]() Features Īccording to The Economic Times, the two most notable features of Paranoid Android are the Halo and the Pie. The Quartz release coincides with supporting additional devices such as the Xiaomi Mi 9. The project was relaunched with a new set of stable releases named "Quartz" (based on Android 10) on 16 April 2020, for a limited set of devices. a They also released concept art for an upcoming feature named "Blink Navigation" based on gestures and Pie navigation, as well as a rundown of a new versioning system. The next goal was Android Pie, with the post saying builds were almost stable, though at the time of the post only two commits under the Pie branch were released on the team's Gerrit. Basic builds were released for the OnePlus 3, 3T, 5 and 5T, as well as the Sony Xperia X, X Compact, XZ Premium, XZ1 and XZ2. The team decided to finish device trees and release sources before discontinuing Oreo MR1. The team apologized for a lack of communication and shared info about current activities. On 27 August 2018, the Google+ page was updated with a new post titled "Being more transparent". The team stated that they were close to release but weren't able to continue without funds and looked to the community for donations. The developers had run out of funds causing their website and Gerrit to shut down and ceasing all work on Oreo builds. 2018, the Paranoid Android Google+ account posted an update on the status of the project. Supported devices include the OnePlus 3 and 3T, Nexus 5X, Nexus 6P, Pixel, and Pixel XL. This version was based on Android 7.1.2 Nougat, with the most notable feature being the return of Pie Controls. On May 31, 2017, the team announced that they released the Nougat flavour of Paranoid Android. On June 8, 2016, Paranoid Android supported Nexus 6P, Nexus 5X, Nexus 6, Nexus 5, Nexus 4, Nexus 7 2013, Nexus 9, OnePlus One, OnePlus 2, and OnePlus X. This announcement coincided with the release of a new version of Paranoid Android, which was based on Android 6.0.1 Marshmallow, with the May security patch, and included new customization features. In June 2016, the Paranoid Android team announced that they were back with new team members. In October 2015, team member Matt Flaming told Android Authority that the project would go on hold. This caused delays to the release of Paranoid Android 5.1 builds. In February 2015, OnePlus hired a handful of key members from the Paranoid Android team to work on its new OxygenOS. Paranoid Android was founded by Paul Henschel. In September 2015, PC Advisor called it the most famous ROM along with CyanogenMod, and The Economic Times called it the second-largest custom Android ROM in the world with over 200 000 users. The latest official version is Topaz, based on Android 13, released on 15 October 2022. Paranoid Android is an open-source operating system for smartphones and tablet computers, based on the Android mobile platform. What's that.Sapphire / 30 November 2021 10 months ago ( )įirmware replacement for Android mobile devices What's that.? (I may be paranoid, but no android) With your opinion which is of no consequence at all When I am king, you will be first against the wall What's that.? (I may be paranoid, but not an android) Please could you stop the noise, I'm trying to get some restįrom all the unborn chicken voices in my head C Cm Cm7/Bb F7(9) Gm Gm7 Gm6 Gm Gm7 Gm6 Cm Cm7/Bb F7(9) Gm Gm7 Gm6 Gm Gm7 Gm6 Cm 5/6/2023 0 Comments Tab suspender opera![]() ![]() Opera appears to have a built-in tab suspender/discarder known as snoozing, however I can't find a way to force a tab to snooze, ie. I install both on Opera and the extension doesn’t work on, which is a huge inconvenience for me. I often use memory-saving extensions like tab suspender (Chrome) or tab discard (Firefox). The feature is enabled by default, at least in the development builds it is available in. Opera Opera Software introduced tab snoozing in Opera 74 (stable is at version 73 at the time of writing), spotted by Techdows. What is the difference between your Extension to Vimium? Note that you only see the options if you enabled the main Tab Sleeping experiment on edge://flags. On Firefox, there’s an extra limit that webextensions can’t create a tab of about:* (except about:blank) or file:///*. So, it’s still not the case that an extension runs on Chrome’s inner PDF viewer.īTW, on Chrome, its default PDF viewer, chrome://* pages and the Chrome Web Store are privileged and no 3rd-party extensions can run on them. The Great Suspender is a free Chrome extension that helps users to. On a timer gets triggered, the suspender replaces the PDF (or Web Store) tab with one of its inner page, and then replace back when you click the page.Īs for the “Vimium C”, it’s one of my personal extensions which is a customized version of Vimium, and the “ PDF Viewer for Vimium C” is a special PDF viewer extension, which is NOT OFFICIAL, compiled from and with some modification. However, this extension is must for them, who often open tons of tabs and windows. The reason that “The Great Suspender” works is that it does not execute operations on the PDF “content”, while Vimium needs. tabXpert supports The Marvellous Suspender and Tab Suspender to suspend. The NSW Gas Rebate helps eligible NSW households cover the costs of their natural gas or LPG (bottled gas), if it is used for basic household needs such as cooking, heating or hot water.If you buy/refill LPG bottled gas, or youre an on supply customer, you can apply for the rebate online. Currently there’s no API from Chrome to allow this. Within a session, you keep your work as active tabs, history of closed tabs. If you have so many tabs open that your computer is slowing down, you don’t need a tab suspender or tab snoozer you need a tab manager. 5/6/2023 0 Comments Xtreme lash eye mackup remover![]() ![]() Free shipping Free shipping Free shipping. You will not notice a difference in feel with the addition of the extensions, and they will not cause your natural lashes to fall out ahead of their natural cycle as other enhancement methods can. Xtreme Lashes Eye Makeup Remover & Facial Cleanser 120 ml brand new in Box. Ask your Xtreme Lashes Stylist if she carries the Xtreme Lashes. Because Xtreme Lashes are designed to replicate real eyelashes, they weigh about as much as a natural lash: practically nothing. Apply the mascara sparingly and remove it gently with a water-based eye makeup remover. As long as you keep up with the touch-up applications, it is almost impossible to tell that you are wearing eyelash extensions. They are flexible yet crimp-resistant, and they move with your natural lashes. Xtreme Lashes are designed to be indistinguishable in size and weight to human lashes. DETAILS INGREDIENTS STORAGE & SHELF LIFE Specifically designed to gently and safely remove eyelash extensions without stripping natural eyelashes of natural oils. The thickness of the extensions applied is determined by the health and thickness of your natural lashes as well as personal preference. Varying individual synthetic lash lengths are chosen to carefully replicate the shape and frame of a natural lash line. Using coconut derived cleansing agents, this refreshing aloe Vera juice formula gently removes all traces of makeup and impurities while six botanical extracts. Each application is customized to suit the individual. Saturate a Lint-Free Applicator with Eye Makeup Remover & Facial Cleanser Gently wipe across lash line, between the lashes and across the eyelid and rinse eye area with water Repeat until all traces of GlideLiner are removed, pat dry, and groom lashes using the Xtreme Lash Styling Wand. ![]() If you're like this editor and after a luxurious lash-lengthening moment, we've rounded up four high-end mascaras worth every penny.With proper application, Xtreme Lashes Eyelash Extensions look and feel completely real. High-quality formulas that evoke a next-level rich experience, Instagram worth tubing, a beautiful wand, the whole "sha-bang." I'll always be ready to put my money where my eyes are. Removes easily with Xtreme Lashes Eye Makeup Remover & Facial Cleanser. Whatever the case, there's something out there for everyone. Design a dense lash look with this double-sided, felt-tip liquid eyeliner. You may be the beauty enthusiast looking to try a mascara that your favorite celebrity swears by, or you may be the person that drugstore brands suit you just fine. Some opt for length, other are biased more towards packaging and tubing and let's not forget the coveted waterproof mascara offering. When it comes to the perfect set of false lashes, we're all after something different. First-world problems, but it's still something. Tuotehaku Päätaso Meikit Silmät Xtreme Lashes Eye Makeup Remover and Facial Cleanser « Takaisin Xtreme Lashes Eye Makeup Remover and Facial Cleanser. ![]() In a beauty editor's opinion, Mascara choices will always say the most about a person, which is why choosing the right product is such a big deal. 5/6/2023 0 Comments Whale watching san diego![]() A couple of great spots include the Birch Aquarium at Scripps, the Cabrillo National Monument and Torrey Pines State Reserve, where the hiking trails offer expansive views of the Pacific. While booking a whale watching tour is well worth the investment, you can still sight the fantastic creatures from places on shore. Blue whales have also been observed acting more like dolphins than whales, rolling over on their to look up at spectators. Although blue whales may seem elusive, they give away their positions by spouting enormous columns of water for up to 30 feet in the air. Incredibly, the largest group of blue whales in the world (up to 3,000!) feed off the California coast during the summer months. These incredible creatures are the largest on Earth–and they’re among the most endangered of the great whales. ![]() These giants are roughly the width of a basketball court, so they’re easy to spot! Summer & Fall Blue Whale Watchingįrom mid-June through September, blue whales can be sighted off San Diego. San Diego features 70 miles of coastline directly in the migration path.Īccording to San Diego’s Birch Aquarium, gray whales generally travel alone or in pods of two or three but more may be seen traveling together during peak migration season. Consequently, winter and spring are a fantastic time for gray whale watching in San Diego.įun fact: It is the longest known distance any mammal migrates on an annual basis and is truly an extraordinary spectacle to observe. They typically spend several months in the warm Baja waters, allowing their young enough time to grow strong for making the journey home in the spring. More than 20,000 gray whales make a 10,000 mile round-trip journey from Alaska to the lagoons of Baja California, where the females give birth to their calves. Winter & Spring Gray Whale Watchingįrom mid-December through April, gray whales are migrating. To see what’s swimming the waters now, you can view a regularly updated photo list of recent sightings. (Note: for safety reasons, children under 2 are not permitted.) Still, what happens if the main stars don’t show up? No worries! If you don’t see a whale or a dolphin on your trip, you can join for free on another tour. San Diego Whale Watch is also the only company in San Diego that offers whale watching all year long. She is the only boat in San Diego used solely for whale watching. This affordable whale watching cruise company takes you out on its boat, the Privateer. The experienced crew know how to track down the amazing whales and dolphins off of San Diego’s beautiful coast. San Diego Whale Watch is a trusted tour company that specializes in showing marine life to excited visitors. ![]() Viral surface proteins are typically presented to the immune system of the host in the form or nanoparticles tens of nm in diameter that present tens of copies of viral proteins. The ability of viral proteins or its domains to induce formation of antibodies depends on the structure and size of antigen. Indeed it has been shown that RBD induces formation of neutralizing antibodies, 9, 15 similar as demonstrated for the related pathogenic coronaviruses 25, 26 and monoclonal antibodies targeting RBD have demonstrated effectiveness in preclinical studies 27, 28. Masking the receptor binding domain by the antibodies can prevent viral binding to the receptor and subsequent infection of target cells. Tertiary structure of the RBD in the complex with the ACE2 receptor has been determined 23, 24. Therefore focusing immune response to the receptor binding domain (RBD) of the Spike protein may increase the probability of inducing neutralizing antibodies. In this case antibodies against diverse surface exposed epitopes of the Spike protein are generated, where some of them may not prevent recognition of the ACE2 receptor or fusion and may even facilitate viral entry through an antibody dependent enhancement mechanism (ADE), as suggested before for SARS CoV and MERS CoV, as a highly undesirable property of a vaccine 20– 22. The majority of vaccines in current clinical trials are based on trimeric full length spike protein or its stabilized devivatives 5, 9, 12– 18, through which the virus attaches to the host cell receptor ACE2 19. Antibodies triggered by a vaccine should preferentially be focused to the domains and epitopes that can prevent viral recognition of the receptor, block viral fusion with cell membrane or interfere with viral replication in other ways. The advantages of DNA plasmid delivery including the speed of adaptation to new targets, cost effective production, stability at ambient temperature without the need for a cold chain make it a potentially attractive vaccination platform, although no DNA plasmid vaccine has been approved for humans so far 10, 11. Different vaccination platforms for the presentation of viral components have been used, including inactivated or attenuated viral particles, purified proteins, mRNA, plasmid DNA, nonreplicating viruses each of them with particular features 4– 9. An effective vaccine should trigger formation of a protective humoral and cell mediated immune response against the viral components that will either inhibit viral entry and replication or kill virus-infected cells. Our results support the advancement of this vaccine platform towards clinical trials.Ĭovid-19 is a pandemic viral disease caused by SARS-CoV-2 that emerged in 2019 and infected >23 millions of people across the world while the number of casualties is approaching 1 million 1– 3 Since we currently lack an effective treatment of the disease and containment of the virus without imposing high cost for the society, vaccination seems to be the best hope to stop the waves of infection that continue to spread throughout the world. The most potent response was observed for the 24-residue β-annulus peptide scaffold that forms large soluble assemblies, that has the advantage of low immunogenicity in comparison to larger scaffolds. Scaffolding strongly augmented the immune response with production of neutralizing antibodies and T cell response including cytotoxic lymphocytes in mice upon immunization with DNA plasmids. Here we prepared and analyzed the response to several DNA vaccines based on genetic fusions of RBD to four different scaffolding domains, namely to the foldon peptide, ferritin, lumazine synthase and β-annulus peptide, presenting from 6 to 60 copies of the RBD on each particle. Small protein antigens typically induce weak immune response while particles measuring tens of nanometers are efficiently presented to B cell follicles and subsequently to follicular germinal center B cells in draining lymph nodes, where B cell proliferation and affinity maturation occurs. The receptor binding domain (RBD) of the surface-exposed spike protein of SARS-CoV-2 represents a suitable target for the induction of neutralizing antibodies upon vaccination. Effective and safe vaccines against SARS-CoV-2 are highly desirable to prevent casualties and societal cost caused by Covid-19 pandemic. 5/6/2023 0 Comments Kodi on firestick![]()
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